Published on: April 12, 2013
by Ashik Siddique for Medical Daily:
A new study explains how cocoa compounds fight the neuronal cell death that leads to Alzheimer’s disease and dementia, on a molecular level in the brain.
It’s well established that chocolate contains pleasure-inducing and mood-enhancing chemicals, and previous studies have touted cocoa’s rich antioxidant and brain-boosting properties. Recent studies have supported the ability of chocolate compounds called flavanols to protect neuron cells against degeneration and dementia.
The new research confirms the antioxidant properties of polyphenols, the larger class of compounds that includes flavanols, and establishes how they work to protect the brain on a cellular level.
Researchers led by Annamaria Cimini of the University of L’Aquila in Italy created cellular models of Alzheimer’s disease, treated with the Aß plaques and Aß peptides associated with neurodegeneration. Applying cocoa polyphenols to those cells triggered the production of brain-derived neurotrophic factor (BDNF), which promotes neuron growth and counteracts cell death caused by oxidative stress.
“Our studies indicate for the first time the cocoa polyphenols do not act only as mere anti-oxidant but they, directly or indirectly, activate the BDNF survival pathway counteracting neuronal death” said Cimini in a statement.
The results, published in the Journal of Cellular Biochemistry, seem to confirm that flavanols in chocolate can indeed protect your brain from neurodegeneration, or at least slow it down.
Since the experiments were only conducted on isolated human cells, it’s unclear how much cocoa powder is necessary or sufficient to gain the BDNF-boosting neuroprotective effects.
Still, baby boomers should take note- in case you needed more convincing to add chocolate to your food intake, the study confirms that at least moderate amounts of cocoa consumption can stave off cognitive impairment and neuronal death.
Other recent research has extended chocolate’s health benefits to relieving persistent coughs, cutting heart attack and stroke risk. But watch out – cocoa also stimulates enkephalin, a naturally occurring brain opioid that drives overconsumption. Chocolate addiction might be a small price to pay for your brain health.
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