Published on: January 27, 2012
by Dementia Today
Pick’s disease is a relatively rare form of dementia that causes a slow shrinking of brain cells due to excess protein build-up. Patients with Pick’s initially exhibit marked personality and behavioral changes, and then a decline in the ability to speak coherently.
While up to seven million Americans may be afflicted with dementia, Pick’s disease accounts for just five percent of all progressive dementias. Because of the manner in which symptoms first appear, it is frequently misdiagnosed in the early stages as depression, mental illness, or Alzheimer’s disease—but Pick’s has its own set of characteristics that set it apart. And although there is no cure, learning about the unique symptoms can help you more quickly identify and manage the disease.
What is Pick’s disease?
According to Arnold Pick, who first described the disease in 1892, Pick’s disease causes an irreversible decline in a person’s functioning over a period of years. Although it is commonly confused with the much more prevalent Alzheimer’s disease, Pick’s disease is a rare disorder that causes the frontal and temporal lobes of the brain, which control speech and personality, to slowly atrophy. It is therefore classified as a frontotemporal dementia, or FTD.
Causes of Pick’s disease
Like Huntington’s disease and Lewy Body disease, Pick’s disease is the result of a build-up of protein in the affected areas of the brain. The accumulation of abnormal brain cells, known as Pick’s bodies, eventually leads to changes in character, socially inappropriate behavior, and poor decision making, progressing to a severe impairment in intellect, memory and speech.
Pick’s disease usually strikes adults between the ages of 40 and 60, and is slightly more common in women than in men. Unfortunately, the cause for Pick’s disease is unknown. A few studies suggest that Pick’s disease may have a genetic component, but most family members are unaffected. Other risk factors are unknown.
Signs and symptoms of Pick’s disease
In contrast to Alzheimer’s disease, where memory loss is the predominate early sign, the first symptoms of Pick’s disease usually involve personality changes or a decline in basic functioning.
While the progression of symptoms in Pick’s disease is fortunately slow, symptoms do worsen over time. The following symptoms are typical of patients with Pick’s disease. More severe symptoms appear in later stages of the illness.
Behavioral signs and symptoms of Pick’s disease
Emotional signs and symptoms of Pick’s disease
Language signs and symptoms of Pick’s disease
Physical signs and symptoms of Pick’s disease
Diagnosis of Pick’s disease
Pick’s disease can only be conclusively determined by a post-mortem examination of the brain, but there are ways to reach a probable diagnosis when symptoms set in. Once diagnosed, patients and caregivers can use practical strategies and professional support to treat the symptoms of the disease.
How is Pick’s disease diagnosed?
Currently, the best methods for reaching a probable diagnosis involve careful symptomatic evaluation, together with brain scans and EEGs. These techniques can help ascertain whether the condition is likely to be Pick’s disease or a related disorder such as Alzheimer’s disease. Although these dementias may be similar, there are clear symptoms that set them apart.
If at least three of the following five distinguishing characteristics are present in the early stages, the diagnosis is likely to be Pick’s rather than Alzheimer’s. Also, as compared with Alzheimer’s disease, obvious mental impairment and memory loss occur later in Pick’s disease patients than in Alzheimer’s patients.
The five distinguishing features of Pick’s disease
Doctors look for at least three of the following to diagnose Pick’s disease.
Treatment and management of Pick’s disease
Treatment for Pick’s disease is usually similar to treatment for Alzheimer’s: symptom management that is aimed at maximizing quality of life. This may include medications to manage particular symptoms, regular supervision, and assistance. Treatment should also include emotional and substantive support for the caregiver. If you or a loved one has Pick’s disease, the following may help control symptoms.
Coping with Pick’s disease
Focusing on the positive aspects of dealing with a terminal disease might seem like an exercise in futility, and yet, there can be unexpected bright spots for patients with Pick’s disease. For instance, at the University of California/San Francisco Medical Center’s Memory and Aging Center, doctors discovered a small group of frontotemporal dementia patients who developed new creative skills in music and art. The artistic talents emerged when the brain cell loss occurred predominantly in the left frontal lobe, which controls functions such as language.
As the ability to communicate through words declined, these patients’ brains somehow accessed other realms of self-expression. So exploring and encouraging the development of latent skills is one way in which Pick’s disease patients can maintain their quality of life and possibly slow the progress of mental deterioration.
Advice for family members
Caring for someone with dementia can be a life-changing experience. People with Pick’s disease may need daily or even around-the-clock care, and taking this on is a huge responsibility. You may feel alone, and the kind of daily challenges you face can be tough on your physical and mental health. If you are a caregiver, remember that it’s important to take measures to prevent burnout and garner your own support—in order to better care for your loved one.
Our event with Dr. Wendy Suzuki explaining how higher levels of physical fitness are associated with better brain structure and higher cognitive function. Highlights video.
Our event with Dr. Wendy Suzuki explaining how higher levels of physical fitness are associated with better brain structure and higher cognitive function. Full video.
Two blood markers, phosphorylated tau 217 (p-tau217) and phosphorylated tau 181 (p-tau181), showed strong diagnostic performances for Alzheimer’s disease and discriminated Alzheimer’s from frontotemporal lobar denervation (FTLD) syndromes and normal cognition, a retrospective study...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.